There is a common saying in Japan, ' ~'.
Don't let alcohol make you overstep the mark
アルコールが(あなたに)一線を越えさせることを許すな => 飲み過ぎ注意
have been adj/pp
In spite of (n)~
Despite (n)~
in spite of the poor weather,
悪天候にも関わらず(〇〇をやり遂げた)
Despite the poor weather,
悪天候にも関わらず(〇〇をやるしかなかった)
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